N-[3-(3-bromo-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-N,N-dimethylamine; 3-(3-bromo-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine -Drug Synthesis Database

【结构式】

【分子编号】37177

【品名】N-[3-(3-bromo-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-N,N-dimethylamine; 3-(3-bromo-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine

【CA登记号】

【分子式】C₁₉H₂₃BrN₂

【分子量】359.3091

【元素组成】C 63.51% H 6.45% Br 22.24% N 7.8%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIV)

The reaction of 3-bromoiminodibenzyl (XIII) with 3-(dimethylamino)propyl chloride (VIII) at 100 C gives N-(3-dimethylaminopropyl)-3-bromoiminodibenzyl (XIV), which is treated with cuprous cyanide in refluxing DMF.

参考文献中间体

合成目标

【1】 Dostert, P. (Hoffmann-La Roche, Inc.); 3-Cyano-N-(N,N-dimethylaminopropyl)-iminodibenzyl and salts thereof. US 4138482 .
【2】 Blancafort, P.; Castaner, J.; Owen, R.T.; Serradell, M.N.; RO-11-2465. Drugs Fut 1981, 6, 1, 41.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VIII)	24581	3-(Dimethylamino)propyl chloride; 3-Chloro-N,N-dimethyl-1-propanamine	5407-04-5	C₅H₁₂ClN	详情	详情
(XIII)	37176	3-bromo-10,11-dihydro-5H-dibenzo[b,f]azepine		C₁₄H₁₂BrN	详情	详情
(XIV)	37177	N-[3-(3-bromo-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-N,N-dimethylamine; 3-(3-bromo-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine		C₁₉H₂₃BrN₂	详情	详情

Extended Information