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【结 构 式】 
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【分子编号】37159 【品名】5-[3-(benzyloxy)-2-formylphenoxy]pentanoic acid 【CA登记号】 |
【 分 子 式 】C19H20O5 【 分 子 量 】328.3648 【元素组成】C 69.5% H 6.14% O 24.36% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)The reaction of 2-hydroxy-6-benzyloxybenzaldehyde (V) with ethyl 5-bromopentanoate (II) by means of K2CO3 and NaI in refluxing ethanol gives ethyl 5-(2-formyl-3-benzyloxyphenoxy)pentanoate (VI), which is hydrolyzed with KOH in ethanol yielding 5-(2-formyl-3-benzyloxyphenoxy)pentanoic acid (VII) Finally, this compound is debenzylated by hydrogenation with H2 over Pd/c in ethanol.
| 【1】 Kneen, G (Glaxo Wellcome plc); Substd. phenol ethers, their preparation, intermediates therefor, pharmaceutical compsns. containing them and the preparation thereof. EP 0022229 . |
| 【2】 Hillier, K.; Castaner, J.; Serradell, M.N.; Blancafort, P.; BW-12C. Drugs Fut 1982, 7, 9, 613. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 37151 | ethyl 5-bromopentanoate | 14660-52-7 | C7H13BrO2 | 详情 | 详情 |
| (V) | 37157 | 2-(benzyloxy)-6-hydroxybenzaldehyde | C14H12O3 | 详情 | 详情 | |
| (VI) | 37158 | ethyl 5-[3-(benzyloxy)-2-formylphenoxy]pentanoate | C21H24O5 | 详情 | 详情 | |
| (VII) | 37159 | 5-[3-(benzyloxy)-2-formylphenoxy]pentanoic acid | C19H20O5 | 详情 | 详情 |
Extended Information