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【结 构 式】 
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【分子编号】37155 【品名】methyl 4-[(5-ethoxy-5-oxopentyl)oxy]-3-formyl-2-hydroxybenzoate 【CA登记号】 |
【 分 子 式 】C16H20O7 【 分 子 量 】324.3306 【元素组成】C 59.25% H 6.22% O 34.53% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IX)The reaction of methyl 2,4-dihydroxy-3-formylbenzoate (VIII) with ethyl 5-bromopentanoate (II) by means of NaH in DMF gives ethyl 5-(2-formyl-3-hydroxy-4-methoxycarbonylphenoxy)pentanoate (IX), which is hydrolyzed with NaOH in water yielding 5-(2-formyl-3-hydroxy-4-carboxyphenoxy)pentanoic acid (X). Finally, this compound is decarboxylated by treatment with acidic alumina in refluxing dioxane-H2O or with copper in quinoline at 210 C.
| 【1】 Kneen, G (Glaxo Wellcome plc); Substd. phenol ethers, their preparation, intermediates therefor, pharmaceutical compsns. containing them and the preparation thereof. EP 0022229 . |
| 【2】 Hillier, K.; Castaner, J.; Serradell, M.N.; Blancafort, P.; BW-12C. Drugs Fut 1982, 7, 9, 613. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 37151 | ethyl 5-bromopentanoate | 14660-52-7 | C7H13BrO2 | 详情 | 详情 |
| (VIII) | 37154 | methyl 3-formyl-2,4-dihydroxybenzoate | C9H8O5 | 详情 | 详情 | |
| (IX) | 37155 | methyl 4-[(5-ethoxy-5-oxopentyl)oxy]-3-formyl-2-hydroxybenzoate | C16H20O7 | 详情 | 详情 | |
| (X) | 37156 | 4-(4-carboxybutoxy)-3-formyl-2-hydroxybenzoic acid | C13H14O7 | 详情 | 详情 |
Extended Information