|
【结 构 式】 
|
【分子编号】37150 【品名】2-Hydroxy-6-methoxybenzaldehyde 【CA登记号】700-44-7 |
【 分 子 式 】C8H8O3 【 分 子 量 】152.14972 【元素组成】C 63.15% H 5.3% O 31.55% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The reaction of 2-hydroxy-6-methoxybenzaldehyde (I) with ethyl 5-bromopentanoate (II) by means of K2CO3 and NaI in refluxing ethanol gives ethyl 5-(2-formyl-3-methoxyphenoxy)pentanoate (III), which is hydrolyzed with NaOH in ethanol - water yielding 5-(2-formyl-3-methoxyphenoxy)pentanoic acid (IV). Finally, this compound is demethylated by treatment with BCl3 in CH2Cl2.
| 【1】 Kneen, G (Glaxo Wellcome plc); Substd. phenol ethers, their preparation, intermediates therefor, pharmaceutical compsns. containing them and the preparation thereof. EP 0022229 . |
| 【2】 Hillier, K.; Castaner, J.; Serradell, M.N.; Blancafort, P.; BW-12C. Drugs Fut 1982, 7, 9, 613. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 37150 | 2-Hydroxy-6-methoxybenzaldehyde | 700-44-7 | C8H8O3 | 详情 | 详情 |
| (II) | 37151 | ethyl 5-bromopentanoate | 14660-52-7 | C7H13BrO2 | 详情 | 详情 |
| (III) | 37152 | ethyl 5-(2-formyl-3-methoxyphenoxy)pentanoate | C15H20O5 | 详情 | 详情 | |
| (IV) | 37153 | 5-(2-formyl-3-methoxyphenoxy)pentanoic acid | C13H16O5 | 详情 | 详情 |
Extended Information