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【结 构 式】 
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【分子编号】37079 【品名】5-Methoxy-2-methyl-1H-indole-3-acetic acid; 2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetic acid 【CA登记号】2882-15-7 |
【 分 子 式 】C12H13NO3 【 分 子 量 】219.24016 【元素组成】C 65.74% H 5.98% N 6.39% O 21.89% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)This compound can be obtained in tvvo different ways: 1) The reaction of 3-bromophthalide (A) with 5-methoxy-2-methyl-1H-indole-3-acetic acid (I) previously salified with triethylamine in refluxing acetone gives (±)-1,3-dihydro-3-oxo-1-isobenzofuranyl-5-methoxy-2-methyl-1H-indole-3-acetate (II). Compound (II) is salified with sodium hydride and then acylated with p-chlorobenzoyl chloride (B). 2) By condensation of the organic salt of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid (III) with 3-bromophthalide (A).
| 【1】 AR 282717 . |
| 【2】 Torriani, H.; Talmetacin. Drugs Fut 1982, 7, 11, 825. |
| 【3】 Los, M.A.; BE 0858897 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (B) | 10295 | p-Chlorobenzoyl chloride; 4-Chlorobenzoyl chloride | 122-01-0 | C7H4Cl2O | 详情 | 详情 |
| (A) | 24560 | 3-Bromophthalide; 3-Bromo-2-benzofuran-1(3H)-one | 6940-49-4 | C8H5BrO2 | 详情 | 详情 |
| (I) | 37079 | 5-Methoxy-2-methyl-1H-indole-3-acetic acid; 2-(5-Methoxy-2-methyl-1H-indol-3-yl)acetic acid | 2882-15-7 | C12H13NO3 | 详情 | 详情 |
| (II) | 37080 | 3-oxo-1,3-dihydro-2-benzofuran-1-yl 2-(5-methoxy-2-methyl-1H-indol-3-yl)acetate | C20H17NO5 | 详情 | 详情 | |
| (III) | 22930 | 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid | C19H16ClNO4 | 详情 | 详情 |
Extended Information