2-(1-[2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)-1-piperazinyl]ethyl]cyclopentyl)acetic acid -Drug Synthesis Database

【结构式】

【分子编号】37032

【品名】2-(1-[2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)-1-piperazinyl]ethyl]cyclopentyl)acetic acid

【CA登记号】

【分子式】C₂₇H₃₁N₃O₄

【分子量】461.56096

【元素组成】C 70.26% H 6.77% N 9.1% O 13.87%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XII)

Condensation of piperazinyl dibenzoazepinone (X) with 3,3-tetramethyleneglutaric anhydride (XI) produced piperazide (XII). Further condensation of (XII) with arginine derivative (IX) using CDI yielded the title compound.

参考文献中间体

合成目标

【1】 Gaida, W.; Schnorrenberg, G.; Dollinger, H.; Doods, H.N.; Esser, F.; Rudolf, K.; Mihm, G. (Boehringer Ingelheim Pharma KG); Novel substd. amino acid derivs., process for their preparation and pharmaceutical compsns. containing them. DE 19816929 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(IX)	37030	(2S)-2-amino-5-[[amino(imino)methyl]amino]-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]pentanamide		C₂₂H₂₈N₈O₃	详情	详情
(X)	37031	11-(1-piperazinyl)-5,11-dihydro-6H-dibenzo[b,e]azepin-6-one		C₁₈H₁₉N₃O	详情	详情
(XI)	34125	8-oxaspiro[4.5]decane-7,9-dione	5662-95-3	C₉H₁₂O₃	详情	详情
(XII)	37032	2-(1-[2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)-1-piperazinyl]ethyl]cyclopentyl)acetic acid		C₂₇H₃₁N₃O₄	详情	详情

Extended Information