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【结 构 式】 
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【分子编号】37013 【品名】methyl 4-[5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-quinoxalinyl)-1H-pyrrol-2-yl]benzoate 【CA登记号】 |
【 分 子 式 】C24H27N3O2 【 分 子 量 】389.4974 【元素组成】C 74.01% H 6.99% N 10.79% O 8.22% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIV)Cyclization of diketone (XII) with ammonium acetate afforded the pyrrole derivative (XIV). The methyl ester group was finally hydrolyzed with NaOH to the target carboxylic acid.
| 【1】 Tai, K.; Yamauchi, T.; Hida, T.; Kikuchi, K.; Nagia, M.; Yoshimura, H.; Tokuhara, N.; Hibi, S.; Synthesis and structure-activity relationships of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxaline derivatives with retinoic acid receptor alpha agonistic activity. J Med Chem 2000, 43, 3, 409. |
| 【2】 Kikuchi, K.; Tagami, K.; Yoshimura, H.; Hibi, S.; Nagai, M.; Abe, S.; Okita, M.; Hida, T.; Higashi, S.; Tokuhara, N.; Kobayashi, S. (Eisai Co., Ltd.); Heterocyclic carboxylic acid derivs. and drugs containing the same. JP 1997071566; US 5977108; WO 9702244 . |
Extended Information