|
【结 构 式】 
|
【分子编号】36994 【品名】4-[2-(1-piperidinyl)ethoxy]benzoic acid 【CA登记号】 |
【 分 子 式 】C14H19NO3 【 分 子 量 】249.3098 【元素组成】C 67.45% H 7.68% N 5.62% O 19.25% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Alkylation of ethyl 4-hydroxybenzoate (I) with 1-(2-chloroethyl)piperidine (II) provided adduct (III). After saponification of the ethyl ester group of (III), the resulting carboxylic acid (IV) was treated with oxalyl chloride to furnish the desired acid chloride (V).
| 【1】 Dantzig, A.H.; Grese, T.A.; Normal, B.H.; Palkowitz, A.D.; Sluka, J.P.; Starling, J.J. II; Winter, M.A. (Eli Lilly and Company); Methods for treating resistant tumors. EP 0773217; JP 2000500138; WO 9717069 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13492 | ethyl p-hydroxybenzoate; ethyl 4-hydroxybenzoate | 120-47-8 | C9H10O3 | 详情 | 详情 |
| (II) | 10117 | 1-(2-Chloroethyl)piperidine; N-(2-Chloroethyl)piperidine | 1932-03-2 | C7H14ClN | 详情 | 详情 |
| (III) | 36993 | ethyl 4-[2-(1-piperidinyl)ethoxy]benzoate | C16H23NO3 | 详情 | 详情 | |
| (IV) | 36994 | 4-[2-(1-piperidinyl)ethoxy]benzoic acid | C14H19NO3 | 详情 | 详情 | |
| (V) | 36995 | 4-[2-(1-piperidinyl)ethoxy]benzoyl chloride | C14H18ClNO2 | 详情 | 详情 |
Extended Information