【结 构 式】 |
【分子编号】43975 【品名】methyl 2-[4-[(tert-butoxycarbonyl)amino]phenyl]-7-hydroxy-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2-dihydro-3-isoquinolinecarboxylate 【CA登记号】 |
【 分 子 式 】C31H32N2O9 【 分 子 量 】576.60316 【元素组成】C 64.57% H 5.59% N 4.86% O 24.97% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XII)Hydrogenolytic removal of the O-benzyl group provided phenol (XII), which was subsequently alkylated with 2-picolyl chloride (XIII) to produce ether (XIV). The Boc protecting group of (XIV) was finally cleaved by treatment with HCl in EtOAc.
【1】 Ikeo, T.; Ukita, T.; Omori, K. (Tanabe Seiyaku Co., Ltd.); Isoquinolinone derivs., process for preparing the same, and their use as phosphodiesterase inhibitors. JP 1998298164; WO 9838168 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(XI) | 43974 | methyl 7-(benzyloxy)-2-[4-[(tert-butoxycarbonyl)amino]phenyl]-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2-dihydro-3-isoquinolinecarboxylate | C38H38N2O9 | 详情 | 详情 | |
(XII) | 43975 | methyl 2-[4-[(tert-butoxycarbonyl)amino]phenyl]-7-hydroxy-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2-dihydro-3-isoquinolinecarboxylate | C31H32N2O9 | 详情 | 详情 | |
(XIII) | 26187 | 2-(Chloromethyl)pyridine | 4377-33-7 | C6H6ClN | 详情 | 详情 |
(XIV) | 43976 | methyl 2-[4-[(tert-butoxycarbonyl)amino]phenyl]-1-oxo-7-(2-pyridinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-1,2-dihydro-3-isoquinolinecarboxylate | C37H37N3O9 | 详情 | 详情 |
Extended Information