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【结 构 式】 
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【分子编号】41080 【品名】 【CA登记号】 |
【 分 子 式 】C7H4BrMgNO3S 【 分 子 量 】286.3887 【元素组成】C 29.36% H 1.41% Br 27.9% Mg 8.49% N 4.89% O 16.76% S 11.2% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)An enantioselective synthesis of the desired (S)-isomer was further developed starting from saccharin (VI). After conversion to the magnesium amide enolate (VII) by means of phenylmagnesium bromide, addition of Grignard reagent (VIII) produced the aryl sulfonimide (IX). Enantioselective reduction to the (S)-sulfonamide (X) was then accomplished using a chiral rhodium catalyst. Then, N-methylation of (X) with yodomethane in the presence of Cs2CO3 provided the title compound.
| 【1】 Condo, A.M.; et al.; Synthesis and molecular modeling studies of 3-aryl-2-methyl-2,3-dihydrobenzo[d]isothiazole 1,1-dioxides: Nonnucleoside reverse transcriptase inhibitors of HIV-1. 219th ACS Natl Meet (March 26 2000, San Francisco) 2000, Abst MEDI 124. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 11298 | 1H-1,2-Benzisothiazole-1,1,3(2H)-trione; Saccharin | 81-07-2 | C7H5NO3S | 详情 | 详情 |
| (VII) | 41080 | C7H4BrMgNO3S | 详情 | 详情 | ||
| (VIII) | 32527 | bromo(3-methylphenyl)magnesium | C7H7BrMg | 详情 | 详情 | |
| (IX) | 41081 | 3-(3-methylphenyl)-1H-1,2-benzisothiazole-1,1-dione | C14H11NO2S | 详情 | 详情 | |
| (X) | 41082 | (3S)-3-(3-methylphenyl)-2,3-dihydro-1H-1,2-benzisothiazole-1,1-dione | C14H13NO2S | 详情 | 详情 |
Extended Information