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【结 构 式】 
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【分子编号】38792 【品名】tert-butyl (1R)-2-[methoxy(methyl)amino]-2-oxo-1-[(tritylsulfanyl)methyl]ethylcarbamate 【CA登记号】 |
【 分 子 式 】C29H34N2O4S 【 分 子 量 】506.66604 【元素组成】C 68.75% H 6.76% N 5.53% O 12.63% S 6.33% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XII)Protected L-cysteine (XI) was converted to aldehyde (XIII) via formation of the corresponding N-methoxy amide (XII) and further reduction with LiAlH4. Reductive condensation of amine (X) with aldehyde (XIII) in the presence of NaBH4CN furnished (XIV). The Boc group of (XIV) was finally deprotected by treatment with trifluoroacetic acid in the presence of triethylsilane.
| 【1】 Dong, Z.X.; Kim, S.H. (Biomeasure Inc.); Inhibitors of prenyl transferases. WO 9800409 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (X) | 38790 | methyl (2S)-2-[([(4R)-3-[(2S,3S)-2-amino-3-methylpentyl]-5,5-dimethyl-1,3-thiazolidin-4-yl]carbonyl)amino]-4-(methylsulfanyl)butanoate | C18H35N3O3S2 | 详情 | 详情 | |
| (XI) | 38791 | (2R)-2-[(tert-butoxycarbonyl)amino]-3-(tritylsulfanyl)propionic acid | 21947-98-8 | C27H29NO4S | 详情 | 详情 |
| (XII) | 38792 | tert-butyl (1R)-2-[methoxy(methyl)amino]-2-oxo-1-[(tritylsulfanyl)methyl]ethylcarbamate | C29H34N2O4S | 详情 | 详情 | |
| (XIII) | 17953 | tert-butyl (1R)-1-formyl-2-(tritylsulfanyl)ethylcarbamate | C27H29NO3S | 详情 | 详情 | |
| (XIV) | 38793 | methyl (2S)-2-([[(4R)-3-((2S,3S)-2-[[(2R)-2-[(tert-butoxycarbonyl)amino]-3-(tritylsulfanyl)propyl]amino]-3-methylpentyl)-5,5-dimethyl-1,3-thiazolidin-4-yl]carbonyl]amino)-4-(methylsulfanyl)butanoate | C45H64N4O5S3 | 详情 | 详情 |
Extended Information