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【结 构 式】

【分子编号】38768

【品名】2,4,6-trichloro-5-isopropylpyrimidine

【CA登记号】

【 分 子 式 】C7H7Cl3N2

【 分 子 量 】225.50416

【元素组成】C 37.28% H 3.13% Cl 47.16% N 12.42%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VI)

In an alternative procedure, condensation of 5-isopropyl-2,4,6-trichloropyrimidine (VI) with 3,5-dimethylbenzylmagnesium chloride (VII) in cold THF produced the 6-benzyl pyrimidine derivative (VIII). Subsequent reaction of (VIII) with sodium methoxide gave dimethoxypyrimidine (IX), which was hydrolyzed to uracil (X) with concentrated HCl. After silylation of (X) with chlorotrimethylsilane and hexamethyldisilazane, alkylation with chloromethyl ethyl ether in the presence of SnCl4 furnished the title compound.

1 Lee, Y.S.; Kim, Y.H.; Regioselective alkylation and arylation at the 6-position of pyrimidine: Syntheisis of 5-alkyl-6-arylmethyl-2,4-pyrimidinediones. Synth Commun 1999, 29, 9, 1503.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(VI) 38768 2,4,6-trichloro-5-isopropylpyrimidine C7H7Cl3N2 详情 详情
(VII) 38769 chloro(3,5-dimethylbenzyl)magnesium C9H11ClMg 详情 详情
(VIII) 38770 2,4-dichloro-6-(3,5-dimethylbenzyl)-5-isopropylpyrimidine C16H18Cl2N2 详情 详情
(IX) 38771 4-(3,5-dimethylbenzyl)-5-isopropyl-6-methoxy-2-pyrimidinyl methyl ether; 4-(3,5-dimethylbenzyl)-5-isopropyl-2,6-dimethoxypyrimidine C18H24N2O2 详情 详情
(X) 38772 6-(3,5-dimethylbenzyl)-5-isopropyl-2,4(1H,3H)-pyrimidinedione C16H20N2O2 详情 详情
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