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【结 构 式】 
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【分子编号】37621 【品名】2-[(2-cyanophenyl)disulfanyl]benzonitrile 【CA登记号】33174-74-2 |
【 分 子 式 】C14H8N2S2 【 分 子 量 】268.363 【元素组成】C 62.66% H 3% N 10.44% S 23.9% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)A new, one-step commercial process for the preparation of 3-(1-piperazinyl)-1,2-benzisothiazole, a key intermediate in the synthesis of ziprasidone has been developed: The reaction of 2-cyanophenyl disulfide (I) with piperazine (II) by means of DMSO and isopropanol at 120-5 C.
| 【1】 Sinay, T.G.; Fox, D.E.; Walinsky, S.W.; Lambert, J.F.; New disulfide route to 3-(1-piperazinyl)-1,2-benzisothiazole. Nucleus for atypical antipsychotic drugs. Org Process Res Dev 1999, 3, 2, 126. |
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