2,5-dimethoxyphenethylamine; 2-(2,5-dimethoxyphenyl)-1-ethanamine -Drug Synthesis Database

【结构式】

【分子编号】36889

【品名】2,5-dimethoxyphenethylamine; 2-(2,5-dimethoxyphenyl)-1-ethanamine

【CA登记号】3600-86-0

【分子式】C₁₀H₁₅NO₂

【分子量】181.23464

【元素组成】C 66.27% H 8.34% N 7.73% O 17.66%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

The reaction of 5-bromopyridin-2-amine (I) with thiocarbonyldiimidazole (II) in acetonitrile gives the thioamide (III), which is finally condensed with 2-(2,5-dimethoxyphenyl)ethylamine (IV) in DMF at 100 C.

参考文献中间体

合成目标

【1】 Vig, R.; Mao, C.; Venkatachalam, T.K.; Tuel-Ahlgren, L.; Sudbeck, E.A.; Uckun, F.M.; Rational design and synthesis of phenethyl-5-bromopyridyl thiourea derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase. Bioorg Med Chem 1998, 6, 10, 1789.
【2】 Uckun, F.M. (Parker Hughes Institute); NNI for treatment of multi-drug resistant HIV. WO 0056736 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12123	5-Bromo-2-pyridinylamine; 5-Bromo-2-pyridinamine; 2-Amino-5-bromopyridine	1072-97-5	C₅H₅BrN₂	详情	详情
(II)	11990	Di(1H-imidazol-1-yl)methanethione; 1,1'-Thiocarbonyldiimidazole	6160-65-2	C₇H₆N₄S	详情	详情
(III)	24645	N-(5-bromo-2-pyridinyl)-1H-imidazole-1-carbothioamide		C₉H₇BrN₄S	详情	详情
(IV)	36889	2,5-dimethoxyphenethylamine; 2-(2,5-dimethoxyphenyl)-1-ethanamine	3600-86-0	C₁₀H₁₅NO₂	详情	详情

Extended Information