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【结 构 式】

【分子编号】36823

【品名】(3aS,8aR)-5-methoxy-3a,8-dimethyl-1-phenethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole; (3aS,8aR)-3a,8-dimethyl-1-phenethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methyl ether

【CA登记号】

【 分 子 式 】C21H26N2O

【 分 子 量 】322.45032

【元素组成】C 78.22% H 8.13% N 8.69% O 4.96%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The reaction of methiodide (I) with 2-phenylethylamine (II) gives N1-phenethylnoresermethole (III), which is demethylated with BBr3 yielding N1-phenethylnoreseroline (IV). Finally, this compound is condensed with 4-isopropylphenyl isocyante (V) to afford the target carbamate.

1 Pei, X.-F.; et al.; Preparation and selective inhibition of human butyrylchlolinesterase by N1-phenethylnorphysostigmine analogues. Med Chem Res 1995, 5, 455-461.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 36822 2-[(2S,3S)-2-hydroxy-5-methoxy-1,3-dimethyl-2,3-dihydro-1H-indol-3-yl]-N,N,N-trimethyl-1-ethanaminium iodide C16H27IN2O2 详情 详情
(II) 18333 Phenethylamine; 2-Phenyl-1-ethanamine 64-04-0 C8H11N 详情 详情
(III) 36823 (3aS,8aR)-5-methoxy-3a,8-dimethyl-1-phenethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole; (3aS,8aR)-3a,8-dimethyl-1-phenethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methyl ether C21H26N2O 详情 详情
(IV) 36824 (3aS,8aR)-3a,8-dimethyl-1-phenethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol C20H24N2O 详情 详情
(V) 34537 4-isopropylphenyl isocyanate; 1-isocyanato-4-isopropylbenzene 31027-31-3 C10H11NO 详情 详情
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