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【结 构 式】 
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【分子编号】36734 【品名】2-[(3-methoxybenzyl)sulfanyl]-3H-imidazo[4,5-c]pyridine; 3-[(3H-imidazo[4,5-c]pyridin-2-ylsulfanyl)methyl]phenyl methyl ether 【CA登记号】 |
【 分 子 式 】C14H13N3OS 【 分 子 量 】271.34284 【元素组成】C 61.97% H 4.83% N 15.49% O 5.9% S 11.82% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Reaction of 3,4-diaminopyridine (I) with potassium O-ethyl dithiocarbonate produced 2-mercaptoimidazo[4,5-c]pyridine (II), which was susequently alkylated with 3-methoxybenzyl bromide (III) and KOH, yielding sulfide (IV). Selective oxidation of (IV) to the target sulfoxide was then achieved by treatment with N-chlorosuccinimide in the presence of NaHCO3 at 0 C.
| 【1】 Jiang, B.; et al.; Preparation of 3-[(aryl)methyl ]sulfinyl-1H-imidazo[4,5-c]pyridine, useful as an antiosteoporotic agent. Org Process Res Dev 1998, 2, 6, 425. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 29128 | 3,4-Diaminopyridine; 3,4-pyridinediamine | 54-96-6 | C5H7N3 | 详情 | 详情 |
| (II) | 36733 | 3H-imidazo[4,5-c]pyridin-2-ylhydrosulfide; 3H-imidazo[4,5-c]pyridine-2-thiol | C6H5N3S | 详情 | 详情 | |
| (III) | 34403 | 1-(bromomethyl)-3-methoxybenzene; 3-(bromomethyl)phenyl methyl ether | C8H9BrO | 详情 | 详情 | |
| (IV) | 36734 | 2-[(3-methoxybenzyl)sulfanyl]-3H-imidazo[4,5-c]pyridine; 3-[(3H-imidazo[4,5-c]pyridin-2-ylsulfanyl)methyl]phenyl methyl ether | C14H13N3OS | 详情 | 详情 |
Extended Information