(3aS,9bR)-11-methoxy-3-methyl-2,3,3a,4,5,9b-hexahydro-1H-naphtho[1,2-a][3]benzazepin-12-ol -Drug Synthesis Database

【结构式】

【分子编号】36622

【品名】(3aS,9bR)-11-methoxy-3-methyl-2,3,3a,4,5,9b-hexahydro-1H-naphtho[1,2-a][3]benzazepin-12-ol

【CA登记号】

【分子式】C₂₀H₂₃NO₂

【分子量】309.40816

【元素组成】C 77.64% H 7.49% N 4.53% O 10.34%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

The condensation of N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine (I) with 2-bromo-1-tetralone (II) by means of K2CO3 in DMF gives the tertiary amine (III), which is reduced with NaBH4 in ethanol to the hydroxyamine (IV). The cyclization of (IV) by means of methanesulfonic acid yields a mixture of cis and trans tetracyclic compounds that is separated by chromatography. The desired trans isomer (V) is monodemethylated by means of EtS-Na in DMF affording a mixture of 11-methoxy,12-hydroxy and 12-methoxy-11-hydroxy compounds that is separated by crystallization. The desired 12-methoxy-11-hydroxy compound (VI) is dehydroxylated by means of 5-chloro-1-phenyltetrazole (CPT) and NaH in hot DMF giving the 12-methoxy compound (VII), which is chlorinated with SO2Cl2 in dichloromethane to afford the racemic 11-chloro-12-methoxy compound rac-(VIII). Optical resolution of rac-(VIII) with (+)-di-p-toluoyl-D-tartaric acid [(+)-DPT] gives (-)(6aS,13bR)(VIII), which is finally demethylated to the target compound with 48% HBr in refluxing acetic acid.

参考文献中间体

合成目标

【1】 Berger, J.G.; et al.; Synthesis and receptor affinities of some conformationally restricted analogues of the dopamine D1 selective ligand (5R)-8-chloro-2,3,4, 5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol. J Med Chem 1989, 32, 8, 1913-21.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	18938	2-(3,4-dimethoxyphenyl)-N-methyl-1-ethanamine; N-(3,4-dimethoxyphenethyl)-N-methylamine	3490-06-0	C₁₁H₁₇NO₂	详情	详情
(II)	20721	2-bromo-3,4-dihydro-1(2H)-naphthalenone		C₁₀H₉BrO	详情	详情
(III)	36619	2-[(3,4-dimethoxyphenethyl)(methyl)amino]-3,4-dihydro-1(2H)-naphthalenone		C₂₁H₂₅NO₃	详情	详情
(IV)	36620	2-[(3,4-dimethoxyphenethyl)(methyl)amino]-1,2,3,4-tetrahydro-1-naphthalenol		C₂₁H₂₇NO₃	详情	详情
(V)	36621	(3aS,9bR)-11-methoxy-3-methyl-2,3,3a,4,5,9b-hexahydro-1H-naphtho[1,2-a][3]benzazepin-12-yl methyl ether; (3aS,9bR)-11,12-dimethoxy-3-methyl-2,3,3a,4,5,9b-hexahydro-1H-naphtho[1,2-a][3]benzazepine		C₂₁H₂₅NO₂	详情	详情
(VI)	36622	(3aS,9bR)-11-methoxy-3-methyl-2,3,3a,4,5,9b-hexahydro-1H-naphtho[1,2-a][3]benzazepin-12-ol		C₂₀H₂₃NO₂	详情	详情
(VII)	36623	(3aS,9bR)-11-methoxy-3-methyl-2,3,3a,4,5,9b-hexahydro-1H-naphtho[1,2-a][3]benzazepine; (3aS,9bR)-3-methyl-2,3,3a,4,5,9b-hexahydro-1H-naphtho[1,2-a][3]benzazepin-11-yl methyl ether		C₂₀H₂₃NO	详情	详情
(VIII)	31779	(3aS,9bR)-12-chloro-11-methoxy-3-methyl-2,3,3a,4,5,9b-hexahydro-1H-naphtho[1,2-a][3]benzazepine; (3aS,9bR)-12-chloro-3-methyl-2,3,3a,4,5,9b-hexahydro-1H-naphtho[1,2-a][3]benzazepin-11-yl methyl ether		C₂₀H₂₂ClNO	详情	详情

Extended Information