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【结 构 式】 
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【分子编号】36605 【品名】2-(7-methoxy-1-naphthyl)propanenitrile 【CA登记号】 |
【 分 子 式 】C14H13NO 【 分 子 量 】211.26336 【元素组成】C 79.59% H 6.2% N 6.63% O 7.57% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Alkylation of (7-methoxy-1-naphthyl)acetonitrile (I) with iodomethane in the presence of NaH gave the corresponding naphthylpropionitrile (II), which was reduced to amine (III) by catalytic hydrogenation over Raney-Ni. Finally, condensation of (III) with butyryl chloride in the presence of triethylamine provided the title butyramide.
| 【1】 Andrieux, J.; Jellimann, C.; Langlois, M.; Mathé-Allainmat, M.; le Gall, M.; Synthesis of beta-substituted naphth-1-yl ethylamido derivatives as new melatoninergic agonists. Bioorg Med Chem 1999, 7, 12, 2945. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 15967 | propanoyl chloride; propionyl chloride | 79-03-8 | C3H5ClO | 详情 | 详情 | |
| (I) | 36604 | 2-(7-methoxy-1-naphthyl)acetonitrile | C13H11NO | 详情 | 详情 | |
| (II) | 36605 | 2-(7-methoxy-1-naphthyl)propanenitrile | C14H13NO | 详情 | 详情 | |
| (III) | 36606 | 2-(7-methoxy-1-naphthyl)-1-propanamine; 2-(7-methoxy-1-naphthyl)propylamine | C14H17NO | 详情 | 详情 |
Extended Information