(Z)-2-(4-chlorophenyl)-3-hydroxy-2-propenal -Drug Synthesis Database

【结构式】

【分子编号】36603

【品名】(Z)-2-(4-chlorophenyl)-3-hydroxy-2-propenal

【CA登记号】

【分子式】C₉H₇ClO₂

【分子量】182.60608

【元素组成】C 59.2% H 3.86% Cl 19.41% O 17.52%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The title compound was prepared by condensation of naltrexone hydrochloride (I) with 2-(4-chlorophenyl)malondialdehyde (II) in the presence of ammonium acetate in refluxing AcOH.

参考文献中间体

合成目标

【1】 Ananthan, S.; Kezar, H.S. III; Carter, R.L.; et al.; Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans. J Med Chem 1999, 42, 18, 3527.
【2】 Ananthan, S. (Southern Research Institute); Pyridomorphinans and use thereof. WO 0112196 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	25079	(1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0(1,13).0(5,17).0(7,18)]octadeca-7(18),8,10-trien-14-one; Naltrexone	16590-41-3	C₂₀H₂₃NO₄	详情	详情
(II)	36603	(Z)-2-(4-chlorophenyl)-3-hydroxy-2-propenal		C₉H₇ClO₂	详情	详情

Extended Information