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【结 构 式】 
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【分子编号】36543 【品名】3-(3-[[tert-butyl(dimethyl)silyl]oxy]propyl)-5-(4H-1,2,4-triazol-4-yl)-2-(trimethylsilyl)-1H-indole; tert-butyl(dimethyl)silyl 3-[5-(4H-1,2,4-triazol-4-yl)-2-(trimethylsilyl)-1H-indol-3-yl]propyl ether 【CA登记号】 |
【 分 子 式 】C22H36N4OSi2 【 分 子 量 】428.7252 【元素组成】C 61.63% H 8.46% N 13.07% O 3.73% Si 13.1% |
合成路线1
该中间体在本合成路线中的序号：(XIV)An alternative procedure for the synthesis of indolylpropanol (VII) is depicted as follows: alkylation of 2-trimethylsilyl-1,3-dithiane (IX) with bromide (X) employing n-butyllithium in cold THF afforded (XI). Subsequent hydrolysis of the thioacetal group of (XI) by means of HgO/HgCl2 provided acylsilane (XII). Iodoaniline (XIII) was prepared by iodination of p-triazolylaniline (IV) with iodine monochloride. Condensation of iodoaniline (XIII) with acylsilane (XII) in the presence of Pd(OAc)2 produced the silylated indole (XIV). Then acid treatment of (XIV) removed both silyl groups to give (VII).
| 【1】 Baker, R.; Bourrain, S.; Castro Pineiro, J.L.; Chambers, M.S.; Guiblin, A.R.; Hobbs, S.C.; Jelley, R.A.; Madin, A.; Matassa, V.G.; Reeve, A.J.; Russell, M.G.N.; Showell, G.A.; Sternfeld, F.; Street, L.J.; Van Niel, M.B. (Merck Sharp & Dohme Ltd.); Azetidine, pyrrolidine and piperidine derivs.. EP 0804434; JP 1998503768; US 5854268; WO 9604274 . |
| 【2】 Chen, C.-Y.; Larsen, R.D. (Merck & Co., Inc.); Palladium catalyzed indolization. US 5808064; WO 9806725 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 36537 | 4-(4H-1,2,4-triazol-4-yl)phenylamine; 4-(4H-1,2,4-triazol-4-yl)aniline | C8H8N4 | 详情 | 详情 | |
| (VII) | 36538 | 3-[5-(4H-1,2,4-triazol-4-yl)-1H-indol-3-yl]-1-propanol | C13H14N4O | 详情 | 详情 | |
| (IX) | 16517 | 1,3-dithian-2-yl(trimethyl)silane; 2-Trimethylsilyl-1,3-dithiane | 13411-42-2 | C7H16S2Si | 详情 | 详情 |
| (X) | 30994 | 3-bromopropyl tert-butyl(dimethyl)silyl ether; (3-bromopropoxy)(tert-butyl)dimethylsilane | C9H21BrOSi | 详情 | 详情 | |
| (XI) | 36540 | tert-butyl(dimethyl)[3-[2-(trimethylsilyl)-1,3-dithian-2-yl]propoxy]silane; tert-butyl(dimethyl)silyl 3-[2-(trimethylsilyl)-1,3-dithian-2-yl]propyl ether | C16H36OS2Si2 | 详情 | 详情 | |
| (XII) | 36541 | 4-[[tert-butyl(dimethyl)silyl]oxy]-1-(trimethylsilyl)-1-butanone | C13H30O2Si2 | 详情 | 详情 | |
| (XIII) | 36542 | 2-iodo-4-(4H-1,2,4-triazol-4-yl)aniline; 2-iodo-4-(4H-1,2,4-triazol-4-yl)phenylamine | C8H7IN4 | 详情 | 详情 | |
| (XIV) | 36543 | 3-(3-[[tert-butyl(dimethyl)silyl]oxy]propyl)-5-(4H-1,2,4-triazol-4-yl)-2-(trimethylsilyl)-1H-indole; tert-butyl(dimethyl)silyl 3-[5-(4H-1,2,4-triazol-4-yl)-2-(trimethylsilyl)-1H-indol-3-yl]propyl ether | C22H36N4OSi2 | 详情 | 详情 |