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【结 构 式】 
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【分子编号】43371 【品名】4-(2,4-dimethoxy-6-methylphenyl)-3-methyl-1H-pyrazol-5-ylamine; 4-(2,4-dimethoxy-6-methylphenyl)-3-methyl-1H-pyrazol-5-amine 【CA登记号】 |
【 分 子 式 】C13H17N3O2 【 分 子 量 】247.297 【元素组成】C 63.14% H 6.93% N 16.99% O 12.94% |
合成路线1
该中间体在本合成路线中的序号：(III)Acylation of 2-amino-5-nitrobenzophenone (I) with phenylacetic acid chloride (II) in refluxing toluene yields derivative (III), whose nitro group is reduced by means of SnCl2 in refluxing EtOAc to afford amine (IV). Coupling of (IV) with protected cysteine (V) by means of isobutyl chloroformate and N-methylmorpholine (NMM) in DMF provides protected derivative (VI), which is finally treated with TFA and Et3SiH in CH2Cl2 to furnish the target compound.
| 【1】 Schlitzer, M.; et al.; Different amino acid replacement in CAAX-tetrapeptide based peptidomimetic farnesyltransferase inhibitors. Archiv der Pharmazie 1999, 332, 4, 124. |
| 【2】 Grabley, S.; Thiericke, R.; Sattler, I. (Hans Knoll Institute for Natural Product Research); Cysteine amides as farnesyl transferase inhibitors. DE 19851714; WO 0027803 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 43770 | (2-amino-5-nitrophenyl)(phenyl)methanone | 1775-95-7 | C13H10N2O3 | 详情 | 详情 |
| (II) | 25890 | 2-phenylacetyl chloride；Phenylacetyl chloride;Phenacetyl chloride;Benzeneacetyl chloride | 103-80-0 | C8H7ClO | 详情 | 详情 |
| (III) | 43371 | 4-(2,4-dimethoxy-6-methylphenyl)-3-methyl-1H-pyrazol-5-ylamine; 4-(2,4-dimethoxy-6-methylphenyl)-3-methyl-1H-pyrazol-5-amine | C13H17N3O2 | 详情 | 详情 | |
| (IV) | 43772 | N-(4-amino-2-benzoylphenyl)-2-phenylacetamide | C21H18N2O2 | 详情 | 详情 | |
| (V) | 38791 | (2R)-2-[(tert-butoxycarbonyl)amino]-3-(tritylsulfanyl)propionic acid | 21947-98-8 | C27H29NO4S | 详情 | 详情 |
| (VI) | 43773 | tert-butyl (1R)-2-[3-benzoyl-4-[(2-phenylacetyl)amino]anilino]-2-oxo-1-[(tritylsulfanyl)methyl]ethylcarbamate | C48H45N3O5S | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(III)The condensation of 2,4-dimethoxy-6-methylphenylacetonitrile (I) with ethyl acetate in the presence of Na metal produced keto nitrile (II). This was cyclized to the amino pyrazole (III) upon treatment with hydrazine and HOAc in refluxing toluene. Subsequent condensation of amino pyrazole (III) with ethyl acetimidate (IV) gave amidine (V), which was converted to the required pyrazolo triazinone (VI) by reaction with diethyl carbonate and NaOEt. Chlorination of (VI) with POCl3 in the presence of N,N-dimethylaniline produced the chloro derivative (VII). This was finally condensed with amine (VIII) to furnish the title compound.
| 【1】 He, L.; Arvanitis, A.G.; Chorvat, R.; Gilligan, P. (DuPont Pharmaceuticals Co.); Azolo triazines and pyrimidines. EP 1049699; WO 9938868 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 43369 | 2-(2,4-dimethoxy-6-methylphenyl)acetonitrile | C11H13NO2 | 详情 | 详情 | |
| (II) | 43370 | 2-(2,4-dimethoxy-6-methylphenyl)-3-oxobutanenitrile | C13H15NO3 | 详情 | 详情 | |
| (III) | 43371 | 4-(2,4-dimethoxy-6-methylphenyl)-3-methyl-1H-pyrazol-5-ylamine; 4-(2,4-dimethoxy-6-methylphenyl)-3-methyl-1H-pyrazol-5-amine | C13H17N3O2 | 详情 | 详情 | |
| (IV) | 43372 | N-[4-(2,4-dimethoxy-6-methylphenyl)-3-methyl-1H-pyrazol-5-yl]ethanimidamide | C15H20N4O2 | 详情 | 详情 | |
| (V) | 12831 | ethyl ethanimidoate | 1000-84-6 | C4H9NO | 详情 | 详情 |
| (VI) | 43372 | N-[4-(2,4-dimethoxy-6-methylphenyl)-3-methyl-1H-pyrazol-5-yl]ethanimidamide | C15H20N4O2 | 详情 | 详情 | |
| (VII) | 43373 | 8-(2,4-dimethoxy-6-methylphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4(3H)-one | C16H18N4O3 | 详情 | 详情 | |
| (VIII) | 43374 | 4-chloro-8-(2,4-dimethoxy-6-methylphenyl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazine; 2-(4-chloro-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-8-yl)-5-methoxy-3-methylphenyl methyl ether | C16H17ClN4O2 | 详情 | 详情 | |
| (IX) | 38928 | (1R)-1-methylpropylamine; (2R)-2-butanamine | C4H11N | 详情 | 详情 |