(1S,4R,5R,9R,10R,12R,13R,17R)-19-isopropyl-5,9-dimethyl-5-(4-morpholinylcarbonyl)-15-oxapentacyclo[10.5.2.0(1,10).0(4,9).0(13,17)]nonadec-18-ene-14,16-dione -Drug Synthesis Database

【结构式】

【分子编号】40154

【品名】(1S,4R,5R,9R,10R,12R,13R,17R)-19-isopropyl-5,9-dimethyl-5-(4-morpholinylcarbonyl)-15-oxapentacyclo[10.5.2.0(1,10).0(4,9).0(13,17)]nonadec-18-ene-14,16-dione

【CA登记号】

【分子式】C₂₈H₃₉NO₅

【分子量】469.6214

【元素组成】C 71.61% H 8.37% N 2.98% O 17.03%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

The reaction of maleopimaric acid (I) with SOCl2 in benzene produces the corresponding acyl chloride (V), which is then condensed with morpholine (A) by means of Et3N in benzene yielding maleopimaryl morpholide (VI). Finally, (VI) is condensed with ethanolamine (B) in refluxing ethanol.

参考文献中间体

合成目标

【1】 Taylor, J.B.; et al. (Aventis Pharma SA); Novel derivatives of maleopimaric acid. DE 2351343; FR 2202691; GB 1417996; JP 49093356; US 3998823 .
【2】 Thorpe, P.; Castaner, J.; RU 18492. Drugs Fut 1977, 2, 9, 623.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(B)	10259	Ethanol amine;Ethanolamine;2-Aminoethanol; 2-Amino-1-ethanol；2-Aminoethyl alcohol	141-43-5	C₂H₇NO	详情	详情
(A)	10388	Morpholine	110-91-8	C₄H₉NO	详情	详情
(I)	40150	(1S,4R,5R,9R,10R,12R,13R,17R)-19-isopropyl-5,9-dimethyl-14,16-dioxo-15-oxapentacyclo[10.5.2.0(1,10).0(4,9).0(13,17)]nonadec-18-ene-5-carboxylic acid		C₂₄H₃₂O₅	详情	详情
(V)	40155	(1S,4R,5R,9R,10R,12R,13R,17R)-19-isopropyl-5,9-dimethyl-14,16-dioxo-15-oxapentacyclo[10.5.2.0(1,10).0(4,9).0(13,17)]nonadec-18-ene-5-carbonyl chloride		C₂₄H₃₁ClO₄	详情	详情
(VI)	40154	(1S,4R,5R,9R,10R,12R,13R,17R)-19-isopropyl-5,9-dimethyl-5-(4-morpholinylcarbonyl)-15-oxapentacyclo[10.5.2.0(1,10).0(4,9).0(13,17)]nonadec-18-ene-14,16-dione		C₂₈H₃₉NO₅	详情	详情

Extended Information