methyl 2-[[2-(4-[[6-(cyclohexyloxy)-2-naphthyl]oxy]phenyl)acetyl]amino]benzoate -Drug Synthesis Database

【结构式】

【分子编号】36346

【品名】methyl 2-[[2-(4-[[6-(cyclohexyloxy)-2-naphthyl]oxy]phenyl)acetyl]amino]benzoate

【CA登记号】

【分子式】C₃₂H₃₁NO₅

【分子量】509.60188

【元素组成】C 75.42% H 6.13% N 2.75% O 15.7%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

4-[6-(Cyclohexyloxy)-2-naphthyloxy]phenylacetic acid (I) was converted to acid chloride (II) by treatment with oxalyl chloride and catalytic DMF. Subsequent coupling of (II) with methyl anthranilate (III) produced the corresponding amide (IV). The methyl ester group of (IV) was finally hydrolyzed with LiOH in THF-MeOH.

参考文献中间体

合成目标

【1】 Takenouchi, K.; Takahashi, K.; Hasegawa, M.; Takeuchi, T.; Komoriya, K. (Teijin Ltd.); Naphthalene deriv.. EP 0763523; US 5945450; WO 9532943 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	36344	2-(4-[[6-(cyclohexyloxy)-2-naphthyl]oxy]phenyl)acetic acid		C₂₄H₂₄O₄	详情	详情
(II)	36345	2-(4-[[6-(cyclohexyloxy)-2-naphthyl]oxy]phenyl)acetyl chloride		C₂₄H₂₃ClO₃	详情	详情
(III)	11161	methyl 2-aminobenzoate; Methyl anthranilate	134-20-3	C₈H₉NO₂	详情	详情
(IV)	36346	methyl 2-[[2-(4-[[6-(cyclohexyloxy)-2-naphthyl]oxy]phenyl)acetyl]amino]benzoate		C₃₂H₃₁NO₅	详情	详情

Extended Information