benzyl 3-methoxy-2,17-dimethyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1(2,6).0(7,28).0(8,13).0(15,19).0(20,27).0(21,26)]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl(methyl)carbamate -Drug Synthesis Database

【结构式】

【分子编号】36329

【品名】benzyl 3-methoxy-2,17-dimethyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1(2,6).0(7,28).0(8,13).0(15,19).0(20,27).0(21,26)]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl(methyl)carbamate

【CA登记号】

【分子式】C₃₇H₃₄N₄O₅

【分子量】614.70092

【元素组成】C 72.3% H 5.58% N 9.11% O 13.01%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The known antibiotic staurosporine (I) was protected as the N-benzyloxycarbonyl derivative (II) by treatment with benzyl chloroformate in the presence of NaHCO3. Subsequent alkylation of (II) at the 2-N atom by treatment with iodomethane and NaH in DMF provided the N-methyl derivative (III). Finally, deprotection of the benzyloxycarbonyl group of (III) by hydrogenation over Pd/C furnished the title compound.

参考文献中间体

合成目标

【1】 Murakata, C.; Sato, A.; Kasai, M.; Morimoto, M.; Akinaga, S. (Kyowa Hakko Kogyo Co., Ltd.); Staurosporin derivatives. EP 0383919; JP 2766360B2; WO 8907105 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	10101	Benzyloxycarbonyl chloride; Benzyl chloroformate; 1-[[(Chlorocarbonyl)oxy]methyl]benzene	501-53-1	C₈H₇ClO₂	详情	详情
(I)	36327	3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1(2,6).0(7,28).0(8,13).0(15,19).0(20,27).0(21,26)]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one	62996-74-1	C₂₈H₂₆N₄O₃	详情	详情
(II)	36328	benzyl 3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1(2,6).0(7,28).0(8,13).0(15,19).0(20,27).0(21,26)]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl(methyl)carbamate		C₃₆H₃₂N₄O₅	详情	详情
(III)	36329	benzyl 3-methoxy-2,17-dimethyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1(2,6).0(7,28).0(8,13).0(15,19).0(20,27).0(21,26)]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl(methyl)carbamate		C₃₇H₃₄N₄O₅	详情	详情

Extended Information