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【结 构 式】 
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【分子编号】36326 【品名】2-imino-5-(4-[4-[(2-imino-4-oxo-1,3-thiazolidin-5-yl)methyl]benzyl]benzyl)-1,3-thiazolidin-4-one 【CA登记号】 |
【 分 子 式 】C21H20N4O2S2 【 分 子 量 】424.54756 【元素组成】C 59.41% H 4.75% N 13.2% O 7.54% S 15.11% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Diazotization of 4,4'-diaminodiphenylmethane (I) with NaNO2 and HCl, followed by copper-catalyzed coupling with methyl acrylate afforded the alpha,alpha'-dichloro diester (II). Subsequent cyclization of (II) with thiourea (III) in refluxing EtOH produced the bis(iminothiazolidinone) (IV). Finally, acid hydrolysis of (IV) yielded the title compound.
| 【1】 Niigata, K.; Takahashi, T.; Iwaoka, K.; Yoneda, T.; Noshiro, O.; Koike, R. (Yamanouchi Pharmaceutical Co., Ltd.); Bisheterocyclic cpd.. EP 0533933; JP 1992511153; WO 9200967 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 14156 | methyl acrylate | 96-33-3 | C4H6O2 | 详情 | 详情 | |
| (I) | 36325 | 4-(4-aminobenzyl)phenylamine; 4-(4-aminobenzyl)aniline | 101-77-9 | C13H14N2 | 详情 | 详情 |
| (II) | 36324 | methyl 2-chloro-3-[4-[4-(2-chloro-3-methoxy-3-oxopropyl)benzyl]phenyl]propanoate | C21H22Cl2O4 | 详情 | 详情 | |
| (III) | 10180 | Thiourea | 62-56-6 | CH4N2S | 详情 | 详情 |
| (IV) | 36326 | 2-imino-5-(4-[4-[(2-imino-4-oxo-1,3-thiazolidin-5-yl)methyl]benzyl]benzyl)-1,3-thiazolidin-4-one | C21H20N4O2S2 | 详情 | 详情 |
Extended Information