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【结 构 式】

【分子编号】36233

【品名】(E)-1-(1H-imidazol-1-yl)-1-octen-3-ol

【CA登记号】

【 分 子 式 】C11H18N2O

【 分 子 量 】194.2768

【元素组成】C 68.01% H 9.34% N 14.42% O 8.24%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

The Oxidation of 1-octyn-3-ol (I) with chromium trioxide gives the 3-oxooctyne (II), which by reaction with imidazole (III) yields (E)-1-(3-oxoocten-1-yl)imidazole (IV). Reduction of this compound with sodium borohydride gives (E)-1,3-hydroxyocten-1-yl)imidazole (V) . Finally, the latter is etherified with benzyl chloride (VI).

1 Pailer, N.; Gutwiller, H.; Mh Chem 1977, 108, Suppl. 1, 653.
2 Bonne, C.; Coquelet, C.; Sincholle, D. (Chauvin Laboratories SA); Therapeutic compsn. based on imidazoles, especially for the treatment of thromboses; imidazoles and process for their preparation. EP 0033432 .
3 Blancafort, P.; Serradell, M.N.; Castaner, J.; CBS-645. Drugs Fut 1983, 8, 10, 843.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 36230 1-Octyn-3-ol 818-72-4 C8H14O 详情 详情
(II) 36231 1-octyn-3-one C8H12O 详情 详情
(III) 10255 Imidazole; 1H-Imidazole 288-32-4 C3H4N2 详情 详情
(IV) 36232 (E)-1-(1H-imidazol-1-yl)-1-octen-3-one C11H16N2O 详情 详情
(V) 36233 (E)-1-(1H-imidazol-1-yl)-1-octen-3-ol C11H18N2O 详情 详情
(VI) 19171 1-(Chloromethyl)benzene; Benzyl chloride 100-44-7 C7H7Cl 详情 详情
Extended Information