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【结 构 式】

【分子编号】36225

【品名】1-methyl-2-(methylsulfanyl)-1H-imidazole; methyl 1-methyl-1H-imidazol-2-yl sulfide

【CA登记号】

【 分 子 式 】C5H8N2S

【 分 子 量 】128.198

【元素组成】C 46.85% H 6.29% N 21.85% S 25.01%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

C-10213-Go has been synthesized from 1-methyl-2-mercaptoimidazole (I). When (I) is methylated with methyl iodide it gives the corresponding thiomethyl derivative (II). Nitration of (II) yields the nitro derivative (III). Oxidation of (III) with monoperphthalic acid gives the sulfone (IV). Condensation of (IV) with 1-methanesulfonyl-2-imidazolidinone (VI) in the presence of sodium hydride affords C-10213-Go.

1 Arya, V.P.; Satranidazole. Drugs Fut 1983, 8, 9, 797.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(B) 13467 Methanesulfonyl chloride;Mesyl chloride;Methylsulfonyl chloride;Methanesulfonic acid chloride;Methanesulfonyl chloride;Methanesulphonyl chloride 124-63-0 CH3ClO2S 详情 详情
(A) 34077 2-carboperoxybenzoic acid C8H6O5 详情 详情
(I) 18783 1-methyl-1H-imidazol-2-ylhydrosulfide; 1-methyl-1H-imidazole-2-thiol 60-56-0 C4H6N2S 详情 详情
(II) 36225 1-methyl-2-(methylsulfanyl)-1H-imidazole; methyl 1-methyl-1H-imidazol-2-yl sulfide C5H8N2S 详情 详情
(III) 36226 methyl 1-methyl-5-nitro-1H-imidazol-2-yl sulfide; 1-methyl-2-(methylsulfanyl)-5-nitro-1H-imidazole C5H7N3O2S 详情 详情
(IV) 36227 1-methyl-2-(methylsulfonyl)-5-nitro-1H-imidazole; methyl 1-methyl-5-nitro-1H-imidazol-2-yl sulfone C5H7N3O4S 详情 详情
(V) 36228 2-imidazolidinone 120-93-4 C3H6N2O 详情 详情
(VI) 36229 1-(methylsulfonyl)-2-imidazolidinone 41730-79-4 C4H8N2O3S 详情 详情
Extended Information