7-methyl-2,3-dihydro-1H-inden-4-yl (3-methyl-2-oxiranyl)methyl ether; 2-methyl-3-[[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]methyl]oxirane -Drug Synthesis Database

【结构式】

【分子编号】36220

【品名】7-methyl-2,3-dihydro-1H-inden-4-yl (3-methyl-2-oxiranyl)methyl ether; 2-methyl-3-[[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]methyl]oxirane

【CA登记号】

【分子式】C₁₄H₁₈O₂

【分子量】218.29572

【元素组成】C 77.03% H 8.31% O 14.66%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

The condensation of 7-methylindan-4-ol (I) with crotyl chloride (II) by means of NaH in DMF gives 1-(7-methylindan-4-yloxy)-trans-2-butuene (III), which is epoxidized with H2O2 in MeCN-MeOH yielding 1-(7-methylindan-4-yloxy)-trans-2,3-epoxybutane (IV). Finally, this compound is treated with isopropylamine (A) in refluxing water.

参考文献中间体

合成目标

【1】 Tucker, H. (AstraZeneca plc); Alkanolamine derivs., process for their preparation and pharmaceutical compsns. containing them. EP 0003664 .
【2】 Castaner, J.; Blancafort, P.; Weetman, D.F.; Serradell, M.N.; ICI-118,551. Drugs Fut 1983, 8, 10, 853.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	23933	2-Propanamine; Isopropylamine	75-31-0	C₃H₉N	详情	详情
(I)	36217	7-methyl-4-indanol	16400-13-8	C₁₀H₁₂O	详情	详情
(II)	36218	(E)-1-chloro-2-butene		C₄H₇Cl	详情	详情
(III)	36219	(E)-2-butenyl 7-methyl-2,3-dihydro-1H-inden-4-yl ether; 4-[(E)-2-butenyloxy]-7-methylindane		C₁₄H₁₈O	详情	详情
(IV)	36220	7-methyl-2,3-dihydro-1H-inden-4-yl (3-methyl-2-oxiranyl)methyl ether; 2-methyl-3-[[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]methyl]oxirane		C₁₄H₁₈O₂	详情	详情

Extended Information