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【结 构 式】 
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【分子编号】36210 【品名】1,3,5-triazinane-2,4,6-trione 【CA登记号】 |
【 分 子 式 】C3H3N3O3 【 分 子 量 】129.07524 【元素组成】C 27.92% H 2.34% N 32.55% O 37.19% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The compound can be prepared in the following way: The reaction of a large excess of epichlorohydrin (II) with cyanuric acid (I) at a temperature above 60 C leads to the 1,3,5-tris(oxiranylmethyl)-substituted derivative (III). Thus, epichlorohydrin functions both as alkylating agent and base. The addition of sodium hydroxide accelerates and completes the hydrogen chloride abstraction after the first step of the reaction. Fractional crystallization of the product gives the alpha and beta stereoisomers.
| 【1】 Budnowski, M.; Preparation and properties of the diastereoisomeic 1,3,5-triglycidyl-s-triazinetriones. Angew Chem 1968, 7, 827. |
| 【2】 Schnegelberger, H.; Budnowski, M. (Henkel KgA); Therapeutic compsns. with a cytostatic action. GB 2044614 . |
| 【3】 Castaner, J.; Serradell, M.N.; Blancafort, P.; Teroxirone. Drugs Fut 1983, 8, 11, 936. |
Extended Information