ethyl (2R,4R)-5-chloro-2,4-dimethyl-5-oxopentanoate -Drug Synthesis Database

【结构式】

【分子编号】36178

【品名】ethyl (2R,4R)-5-chloro-2,4-dimethyl-5-oxopentanoate

【CA登记号】

【分子式】C₉H₁₅ClO₃

【分子量】206.669

【元素组成】C 52.31% H 7.32% Cl 17.15% O 23.22%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The ethanolysis of 2,4-dimethylglutaric anhydride (I) gives the monoethyl ester of 2,4-dimethylglutaric acid (II), which by reaction with oxalyl chloride is converted into the monoacyl chloride (III). Finally, this compound is condensed with indoline-2-carboxylic acid (IV) hy means of K2CO3 in pyridine.

参考文献中间体

合成目标

【1】 Gruenfeld, N (Novartis AG); 1-Carboxyalkanoylindolin-2-carboxylic acids and derivs. thereof, processes for their preparation, and pharmaceutical compsns. containing these cpds. as well as their use. EP 0050850 .
【2】 Serradell, M.N.; Castaner, J.; Blancafort, P.; CGS-13945. Drugs Fut 1983, 8, 12, 1010.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	36176	3,5-dimethyldihydro-2H-pyran-2,6(3H)-dione	C₇H₁₀O₃	详情	详情
(II)	36177	(2R,4R)-5-ethoxy-2,4-dimethyl-5-oxopentanoic acid	C₉H₁₆O₄	详情	详情
(III)	36178	ethyl (2R,4R)-5-chloro-2,4-dimethyl-5-oxopentanoate	C₉H₁₅ClO₃	详情	详情
(IV)	34307	(2S)-2,3-dihydro-1H-indole-2-carboxylic acid	C₉H₉NO₂	详情	详情

Extended Information