2,6-dichloro-N(4),N(4),N(8),N(8)-tetraethylpyrimido[5,4-d]pyrimidine-4,8-diamine; N-[2,6-dichloro-8-(diethylamino)pyrimido[5,4-d]pyrimidin-4-yl]-N,N-diethylamine -Drug Synthesis Database

【结构式】

【分子编号】36174

【品名】2,6-dichloro-N(4),N(4),N(8),N(8)-tetraethylpyrimido[5,4-d]pyrimidine-4,8-diamine; N-[2,6-dichloro-8-(diethylamino)pyrimido[5,4-d]pyrimidin-4-yl]-N,N-diethylamine

【CA登记号】

【分子式】C₁₄H₂₀Cl₂N₆

【分子量】343.25864

【元素组成】C 48.99% H 5.87% Cl 20.66% N 24.48%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Reaction of 2,4,6,8-tetrachloropyrimido[5,4-d]pyrimidine (I) with diethylamine (II) yields (III), which is converted into RA-642 by heating with 2'-hydroxyethyl-2'-methoxyethylamine (IV).

参考文献中间体

合成目标

【1】 Roch, R.; Kadatz, R.; Ihrig, H.; DE 2300661 .
【2】 Pichler, L.; Heckel, A.; RA-642. Drugs Fut 1983, 8, 12, 1023.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	36173	2,4,6,8-tetrachloropyrimido[5,4-d]pyrimidine		C₆Cl₄N₄	详情	详情
(II)	24486	Diethylamine; N,N-Diethylamine	109-89-7	C₄H₁₁N	详情	详情
(III)	36174	2,6-dichloro-N(4),N(4),N(8),N(8)-tetraethylpyrimido[5,4-d]pyrimidine-4,8-diamine; N-[2,6-dichloro-8-(diethylamino)pyrimido[5,4-d]pyrimidin-4-yl]-N,N-diethylamine		C₁₄H₂₀Cl₂N₆	详情	详情
(IV)	36175	2-[(2-methoxyethyl)amino]-1-ethanol		C₅H₁₃NO₂	详情	详情

Extended Information