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【结 构 式】 
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【分子编号】36063 【品名】(3R,5S)-1-(3-chloropropyl)-3,5-dimethylpiperazine 【CA登记号】 |
【 分 子 式 】C9H19ClN2 【 分 子 量 】190.71604 【元素组成】C 56.68% H 10.04% Cl 18.59% N 14.69% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The reaction of 3-chloropropanol (I) with 2,6-dimethylpiperazine (II) by means of Na2CO3 in refluxing glycol monomethyl ether gives 3-(3,5-dimethyl-1-piperazinyl)propanol (III), which by reaction with refluxing SOCl2 is converted into 3-(3,5-dimethylpiperazinyl)propyl chloride (IV). Finally, this compound is condensed with carbazole (V) by means of NaH in hot DMF; a final treatment with aqueous HCl yields the dihydrochloride.
| 【1】 Harfenist, M.; Jogner, C.T. (Glaxo Wellcome Inc.); Carbazole compounds and medicinal use thereof. DD 147110; EP 0012208; EP 0051321; US 4379160 . |
| 【2】 Blancafort, P.; Hilier, K.; Serradell, M.N.; Castaner, J.; BW-234U. Drugs Fut 1983, 8, 4, 303. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 20848 | (2R,6S)-2,6-dimethylpiperazine | C6H14N2 | 详情 | 详情 | |
| (II) | 19490 | 3-chloro-1-propanol | 627-30-5 | C3H7ClO | 详情 | 详情 |
| (III) | 36062 | 3-[(3R,5S)-3,5-dimethylpiperazinyl]-1-propanol | C9H20N2O | 详情 | 详情 | |
| (IV) | 36063 | (3R,5S)-1-(3-chloropropyl)-3,5-dimethylpiperazine | C9H19ClN2 | 详情 | 详情 | |
| (V) | 36064 | 9H-carbazole | 86-74-8 | C12H9N | 详情 | 详情 |
Extended Information