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【结 构 式】 
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【分子编号】36053 【品名】4-ethyl-2-pyridinecarboxylic acid 【CA登记号】 |
【 分 子 式 】C8H9NO2 【 分 子 量 】151.165 【元素组成】C 63.56% H 6% N 9.27% O 21.17% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The condensation of 4-ethylpyridine-2-carboxylic acid (I) with methyl-6-amino-7-chloro-6,7,8-trideoxy-1-thio-L-threo-alpha-D-galacto-octopyranoside (II) by means of isobutyl chloroformate (A) and triethylamine in acetonitrile gives the corresponding amide (III), which is then hydrogenated with H2 over PtO2 in methanol - water - HCl.
| 【1】 Hillier, K.; Serradell, M.N.; Blancafort, P.; Castaner, J.; Pirlimycin hydrochloride. Drugs Fut 1983, 8, 4, 338. |
| 【2】 Birkenmeyer, R.D. (Pharmacia Corp.); Novel antibiotics, their preparation and their use. BE 0886301 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 13423 | 1-[(Chlorocarbonyl)oxy]-2-methylpropane; Isobutyl chloroformate;isobutyl carbonochloridate | 543-27-1 | C5H9ClO2 | 详情 | 详情 |
| (I) | 36053 | 4-ethyl-2-pyridinecarboxylic acid | C8H9NO2 | 详情 | 详情 | |
| (II) | 36054 | (2R,3R,4S,5R,6R)-2-[(1S,2S)-1-amino-2-chloropropyl]-6-(methylsulfanyl)tetrahydro-2H-pyran-3,4,5-triol | C9H18ClNO4S | 详情 | 详情 | |
| (III) | 36055 | N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)tetrahydro-2H-pyran-2-yl]propyl]-4-ethyl-2-pyridinecarboxamide | C17H25ClN2O5S | 详情 | 详情 |
Extended Information