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【结 构 式】

【分子编号】35859

【品名】methyl 4-[4-(7-ethyl-4-methyl-1-benzofuran-2-yl)-4-oxobutanoyl]benzoate

【CA登记号】

【 分 子 式 】C23H22O5

【 分 子 量 】378.42468

【元素组成】C 73% H 5.86% O 21.14%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The condensation of 7-ethyl-4-methylbenzofuran-2-carbaldehyde (I) with 4-acryloylbenzoic acid methyl ester (II) by means of 3-benzyl-5-(hydroxymethyl)-4-methylthiazolium chloride (BHMT) in hot DMF gives the 1,4-butanedione (III), which is cyclized with ammonium acetate in refluxing methanol to yield the substituted pyrrole (IV). Finally, the ester group of (IV) is hydrolyzed with NaOH in refluxing ethanol/water.

1 Tagami, K.; Yoshimura, H.; Nagai, M.; Hibi, S.; Kikuchi, K.; Sato, T.; Okita, M.; Okamoto, Y.; Nagasaka, Y.; Kobayashi, N.; Hida, T.; Tai, K.; Tokuhara, N.; Kobayashi, S. (Eisai Co., Ltd.); Fused-ring carboxylic acid derivs.. EP 0889032; US 6110959; US 6121309; WO 9734869 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 35858 7-ethyl-4-methyl-1-benzofuran-2-carbaldehyde C12H12O2 详情 详情
(II) 35857 methyl 4-acryloylbenzoate C11H10O3 详情 详情
(III) 35859 methyl 4-[4-(7-ethyl-4-methyl-1-benzofuran-2-yl)-4-oxobutanoyl]benzoate C23H22O5 详情 详情
(IV) 35860 methyl 4-[5-(7-ethyl-4-methyl-1-benzofuran-2-yl)-1H-pyrrol-2-yl]benzoate C23H21NO3 详情 详情
Extended Information