Spironolactone -Drug Synthesis Database

【结构式】

【分子编号】35799

【品名】Spironolactone

【CA登记号】52-01-7

【分子式】C₂₄H₃₂O₄S

【分子量】416.58168

【元素组成】C 69.2% H 7.74% O 15.36% S 7.7%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

Elimination of the thioacetyl group of spironolactone (VII) by treatment with NaOMe yielded canrenone (VIII). The title compound was then obtained by 1,6-conjugate addition of thiol (VI) to the dienone (VIII) in the presence of metallic sodium at 60 C.

参考文献中间体

合成目标

【1】 Leblanc, G.; Noël, P.; Poirier, D.; Labrie, F.; Breton, E.; Luu-The, V.; Tremblay, M.R.; Spironolactone-related inhibitors of type II 17beta-hydroxysteroid dehydrogenase: Chemical synthesis, receptor binding affinities, and proliferative/antiproliferative activities. Bioorg Med Chem 1999, 7, 6, 1013.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VI)	35798	4-[2-(1-piperidinyl)ethoxy]benzylhydrosulfide; [4-[2-(1-piperidinyl)ethoxy]phenyl]methanethiol		C₁₄H₂₁NOS	详情	详情
(VII)	35799	Spironolactone	52-01-7	C₂₄H₃₂O₄S	详情	详情
(VIII)	18027	3-Oxopregna-4,6-diene-21,17-carbolactone	976-71-6	C₂₂H₂₈O₃	详情	详情

Extended Information