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【结 构 式】

【分子编号】35669

【品名】Pamaqueside

【CA登记号】150332-35-7

【 分 子 式 】C39H62O14

【 分 子 量 】754.91288

【元素组成】C 62.05% H 8.28% O 29.67%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The acetalization of Hecogenyl beta-O-cellobioside (I) with 4-methoxybenzaldehyde diethyl acetal (II) by means of pyridinium tosylate in THF gives the acetal (III), which is acylated with 2-methoxyacetyl chloride (IV) by means of pyridine and DMAP in dichloromethane yielding the pentaacetate (V). The elimination of the acetal group of (V) with H2 over Pd/C in ethyl acetate affords the dihydroxy compound (VI).

1 Urban, F.J.; et al.; Process research and large-scale synthesis of 4'',6''-bis((2-fluorophenyl)carbomoyl)hecogenyl beta-O-cellobioside: A potent cholesterol absorption inhibitor. Org Process Res Dev 1998, 2, 2, 66.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 35669 Pamaqueside 150332-35-7 C39H62O14 详情 详情
(II) 35670 1-(diethoxymethyl)-4-methoxybenzene; 4-(diethoxymethyl)phenyl methyl ether C12H18O3 详情 详情
(III) 35671   C47H68O15 详情 详情
(IV) 13429 2-Methoxyacetyl chloride; Methoxyacetyl chloride 38870-89-2 C3H5ClO2 详情 详情
(V) 35672   C62H88O25 详情 详情
(VI) 35673   C54H82O24 详情 详情
Extended Information