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【结 构 式】 
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【分子编号】35656 【品名】(2R)-4-[6-([[3,5-bis(trifluoromethyl)benzyl]amino]carbonyl)-5-(4-methylphenyl)-8-oxo[1,7]naphthyridin-7(8H)-yl]-2-methylbutyl methanesulfonate 【CA登记号】 |
【 分 子 式 】C31H29F6N3O5S 【 分 子 量 】669.6448992 【元素组成】C 55.6% H 4.37% F 17.02% N 6.28% O 11.95% S 4.79% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVI)Intermediate (XV) was converted to mesylate (XVI) with methanesulfonyl chloride and Et3N. Finally, cyclization of (XVI) in the presence of NaH in refluxing THF produced the target diazocinonaphthyridine.
| 【1】 Tanaka, T.; Kawada, M.; Ishichi, Y.; Kamo, I.; Ishimaru, T.; Fujishima, A.; Ikeura, Y.; Natsugari, H.; Doi, T.; Kasahara, F.; Axially chiral 1,7-naphthyridine-6-carboxamide derivatives as orally active tachykinin NK1 receptor antagonists: Synthesis, antagonistic activity, and effects on bladder functions. J Med Chem 1999, 42, 19, 3982. |
| 【2】 Natsugari, H.; Ishimaru, T.; Doi, T.; Ikeura, Y.; Kimura, C. (Takeda Chemical Industries, Ltd.); Cyclic cpds., their production and use as tachykinin receptor antagonists. CA 2172421; EP 0733632; JP 1997263585; JP 1997263587; US 5786352 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XV) | 35655 | N-[3,5-bis(trifluoromethyl)benzyl]-7-[(3R)-4-hydroxy-3-methylbutyl]-5-(4-methylphenyl)-8-oxo-7,8-dihydro[1,7]naphthyridine-6-carboxamide | C30H27F6N3O3 | 详情 | 详情 | |
| (XVI) | 35656 | (2R)-4-[6-([[3,5-bis(trifluoromethyl)benzyl]amino]carbonyl)-5-(4-methylphenyl)-8-oxo[1,7]naphthyridin-7(8H)-yl]-2-methylbutyl methanesulfonate | C31H29F6N3O5S | 详情 | 详情 |
Extended Information