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【结 构 式】 
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【分子编号】35626 【品名】2-(palmitoyloxy)-1-[(phosphonooxy)methyl]ethyl palmitate 【CA登记号】 |
【 分 子 式 】C35H69O8P 【 分 子 量 】648.901822 【元素组成】C 64.78% H 10.72% O 19.72% P 4.77% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The synthesis of the title compound has been reported by two procedures. Coupling of dipalmitoylphosphatidic acid (I) to 3'-azido-3'-deoxythimidine (AZT) (II) was carried out using triisopropylbenzenesulfonyl chloride in pyridine to provide the target phosphate diester.
| 【1】 Hostetler, K.Y.; Felgner, J.; Richman, D.D.; Selleseth, D.W.; Gardner, M.F.; Ellis, M.N.; Felgner, P.L.; Ricci, J.; Sridhar, C.N.; Phosphatidylazidothymidine and phosphatidyl-ddC: Assessment of uptake in mouse lymphoid tissues and antiviral activities in human immunodeficiency virus-infected cells and in rauscher leukemia virus-infected mice. Antimicrob Agents Chemother 1994, 38, 12, 2792. |
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