N-[(1S)-3-diazo-1-(dodecylsulfanyl)-2-oxopropyl]acetamide -Drug Synthesis Database

【结构式】

【分子编号】35478

【品名】N-[(1S)-3-diazo-1-(dodecylsulfanyl)-2-oxopropyl]acetamide

【CA登记号】

【分子式】C₁₇H₃₁N₃O₂S

【分子量】341.51816

【元素组成】C 59.79% H 9.15% N 12.3% O 9.37% S 9.39%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

The alkylation of N-acetyl-L-cysteine (I) with dodecyl bromide (II) by means of ammonia in methanol gives N-acetyl-S-dodecyl-L-cysteine (III), which is treated with isobutyl chloroformate and N-methylmorpholine (NMM) in THF yielding the mixed anhydride (IV). The reaction of (IV) with diazomethane in ethyl ether affords the diazoketone (V), which is finally treated with HCl in ethyl acetate.

参考文献中间体

合成目标

【1】 Narla, R.K.; Uckun, F.M.; Perry, D.A. (Parker Hughes Institute); Alkyl ketones as potent anti-cancer agents. WO 0000469 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	35475	(2S)-2-(acetamido)-2-sulfanylethanoic acid		C₄H₇NO₃S	详情	详情
(II)	24062	1-bromododecane	143-15-7	C₁₂H₂₅Br	详情	详情
(III)	35476	(2S)-2-(acetamido)-2-(dodecylsulfanyl)ethanoic acid		C₁₆H₃₁NO₃S	详情	详情
(IV)	35477			C₂₁H₃₉NO₅S	详情	详情
(V)	35478	N-[(1S)-3-diazo-1-(dodecylsulfanyl)-2-oxopropyl]acetamide		C₁₇H₃₁N₃O₂S	详情	详情

Extended Information