合成路线1

The intermediate toluene-4-thiosulfonic acid S-(4-amino-2-tert-butyl-5-methylphenyl) ester (VII) has been obtained as follows: the reduction of 5-tert-butyl-2-methylnitrobenzene (VIII) with H2 over RaNi in methanol gives the corresponding aniline (IX), which is treated with sodium thiocyanate and Br2 in methanol to afford 5-tert-butyl-2-methyl-4-thiocyanatoaniline (X). The reaction of (X) with tert-butoxycarbonyl anhydride (Boc2O) in THF gives the imidodicarbonic ester (XI), which is treated with dithiothreitol in ethanol/water to yield the bis sulfanyl compound (XII). The sulfonation of (XII) with tosyl bromide and triethylamine in CCl4 affords the bis toluene-4-thiosulfonate (XIII), which is finally deprotected with HCl in dichloromethane to provide the target intermediate (VII).