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【结 构 式】 
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【分子编号】35320 【品名】2-amino-9-[[(2-methoxy-1,3-dioxan-5-yl)oxy]methyl]-1,9-dihydro-6H-purin-6-one 【CA登记号】 |
【 分 子 式 】C11H15N5O5 【 分 子 量 】297.2708 【元素组成】C 44.44% H 5.09% N 23.56% O 26.91% |
合成路线1
该中间体在本合成路线中的序号：(XI)The reaction of ganciclovir (I) with trimethyl orthoformate and TFA in DMF gives the cyclic orthoester (XI), which is treated with formic acid in DMF/water to yield ganciclovir O-monoformate (XII). The condensation of (XII) with N-benzyloxycarbonyl-L-valine-N-carboxyanhydride (III) by means of triethylamine in DMF affords the expected monovalinate (XIII), which is deformylated with HCl in methanol/dichloromethane to give the previously reported monoprotected valganciclovir derivative (IV). The preceding reaction sequence can also be performed by substituting trimethyl orthoformate with other orthoesters such as benzyl orthoformate, ethyl orthoacetate, methyl orthoacetate or ethyl orthopropionate.
| 【1】 Sorbera, L.A.; Castañer, J.; Castañer, R.M.; Valganciclovir Hydrochloride. Drugs Fut 2000, 25, 5, 474. |
| 【2】 Arzeno, H.B.; Humphreys, E.R.; Wong, J.-W.; Roberts, C.R. (F. Hoffmann-La Roche AG); Process for preparing ganciclovir derivs.. US 5840890; WO 9727197 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 35312 | 2-amino-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-1,9-dihydro-6H-purin-6-one | C9H13N5O4 | 详情 | 详情 | |
| (III) | 29555 | benzyl (4S)-4-isopropyl-2,5-dioxo-1,3-oxazolidine-3-carboxylate | 158257-41-1 | C14H15NO5 | 详情 | 详情 |
| (IV) | 35314 | 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl (2S)-2-[[(benzyloxy)carbonyl]amino]-3-methylbutanoate | C22H28N6O7 | 详情 | 详情 | |
| (XI) | 35320 | 2-amino-9-[[(2-methoxy-1,3-dioxan-5-yl)oxy]methyl]-1,9-dihydro-6H-purin-6-one | C11H15N5O5 | 详情 | 详情 | |
| (XII) | 35320 | 2-amino-9-[[(2-methoxy-1,3-dioxan-5-yl)oxy]methyl]-1,9-dihydro-6H-purin-6-one | C11H15N5O5 | 详情 | 详情 | |
| (XIII) | 35322 | 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]-3-(formyloxy)propyl (2S)-2-[[(benzyloxy)carbonyl]amino]-3-methylbutanoate | C23H28N6O8 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(XII)The reaction of ganciclovir (I) with trimethyl orthoformate and TFA in DMF gives the cyclic orthoester (XI), which is treated with formic acid in DMF/water to yield ganciclovir O-monoformate (XII). The condensation of (XII) with N-benzyloxycarbonyl-L-valine-N-carboxyanhydride (III) by means of triethylamine in DMF affords the expected monovalinate (XIII), which is deformylated with HCl in methanol/dichloromethane to give the previously reported monoprotected valganciclovir derivative (IV). The preceding reaction sequence can also be performed by substituting trimethyl orthoformate with other orthoesters such as benzyl orthoformate, ethyl orthoacetate, methyl orthoacetate or ethyl orthopropionate.
| 【1】 Sorbera, L.A.; Castañer, J.; Castañer, R.M.; Valganciclovir Hydrochloride. Drugs Fut 2000, 25, 5, 474. |
| 【2】 Arzeno, H.B.; Humphreys, E.R.; Wong, J.-W.; Roberts, C.R. (F. Hoffmann-La Roche AG); Process for preparing ganciclovir derivs.. US 5840890; WO 9727197 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 35312 | 2-amino-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-1,9-dihydro-6H-purin-6-one | C9H13N5O4 | 详情 | 详情 | |
| (III) | 29555 | benzyl (4S)-4-isopropyl-2,5-dioxo-1,3-oxazolidine-3-carboxylate | 158257-41-1 | C14H15NO5 | 详情 | 详情 |
| (IV) | 35314 | 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl (2S)-2-[[(benzyloxy)carbonyl]amino]-3-methylbutanoate | C22H28N6O7 | 详情 | 详情 | |
| (XI) | 35320 | 2-amino-9-[[(2-methoxy-1,3-dioxan-5-yl)oxy]methyl]-1,9-dihydro-6H-purin-6-one | C11H15N5O5 | 详情 | 详情 | |
| (XII) | 35320 | 2-amino-9-[[(2-methoxy-1,3-dioxan-5-yl)oxy]methyl]-1,9-dihydro-6H-purin-6-one | C11H15N5O5 | 详情 | 详情 | |
| (XIII) | 35322 | 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]-3-(formyloxy)propyl (2S)-2-[[(benzyloxy)carbonyl]amino]-3-methylbutanoate | C23H28N6O8 | 详情 | 详情 |