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【结 构 式】 
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【分子编号】35315 【品名】2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]-3-[((2S)-2-[[(benzyloxy)carbonyl]amino]-3-methylbutanoyl)oxy]propyl (2S)-2-[[(benzyloxy)carbonyl]amino]-3-methylbutanoate 【CA登记号】 |
【 分 子 式 】C35H43N7O10 【 分 子 量 】721.7676 【元素组成】C 58.24% H 6% N 13.58% O 22.17% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)The condensation of ganciclovir (I) with the activated L-valine derivative (III) by means of triethylamine in DMF gives the O,O'-bis(valyl)ganciclovir derivative (V), which by selective removal of one of the L-valine groups with propylamine in hexane yields the previously reported monoprotected valganciclovir derivative (IV).
| 【1】 Sorbera, L.A.; Castañer, J.; Castañer, R.M.; Valganciclovir Hydrochloride. Drugs Fut 2000, 25, 5, 474. |
| 【2】 Arzeno, H.B. (F. Hoffmann-La Roche AG); Process for preparing purine derivs.. US 5700936; WO 9727195 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 35312 | 2-amino-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-1,9-dihydro-6H-purin-6-one | C9H13N5O4 | 详情 | 详情 | |
| (III) | 29555 | benzyl (4S)-4-isopropyl-2,5-dioxo-1,3-oxazolidine-3-carboxylate | 158257-41-1 | C14H15NO5 | 详情 | 详情 |
| (IV) | 35314 | 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl (2S)-2-[[(benzyloxy)carbonyl]amino]-3-methylbutanoate | C22H28N6O7 | 详情 | 详情 | |
| (V) | 35315 | 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]-3-[((2S)-2-[[(benzyloxy)carbonyl]amino]-3-methylbutanoyl)oxy]propyl (2S)-2-[[(benzyloxy)carbonyl]amino]-3-methylbutanoate | C35H43N7O10 | 详情 | 详情 |
Extended Information