bis(2-methylphenyl)methanone oxime -Drug Synthesis Database

【结构式】

【分子编号】35193

【品名】bis(2-methylphenyl)methanone oxime

【CA登记号】

【分子式】C₁₅H₁₅NO

【分子量】225.29024

【元素组成】C 79.97% H 6.71% N 6.22% O 7.1%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Treatment of 2,2'-dimethylbenzophenone (I) with hydroxylamine afforded oxime (II), which was reduced to the benzhydryl amine (III) with sodium metal in liquid ammonia. Condensation of (III) with bromoacetyl bromide (IV) then produced the target amide (V).

参考文献中间体

合成目标

【1】 Chiou, W.J.; Liu, G.; Kozmina, N.S.; Opgenorth, T.J.; Winn, M.; Dixon, D.B.; Nguyen, B.; von geldern, T.W.; Marsh, K.C.; Design, synthesis, and activity of a series of pyrrolidine-3-carboxylic acid-based, highly specific, orally active ETB antagonists containing a diphenylmethylamine acetamide side chain. J Med Chem 1999, 42, 18, 3679.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	32201	Hydroxylamine	7803-49-8	H₃NO	详情	详情
(I)	35192	bis(2-methylphenyl)methanone		C₁₅H₁₄O	详情	详情
(II)	35193	bis(2-methylphenyl)methanone oxime		C₁₅H₁₅NO	详情	详情
(III)	35194	bis(2-methylphenyl)methanamine; bis(2-methylphenyl)methylamine		C₁₅H₁₇N	详情	详情
(IV)	14005	2-Bromoacetyl bromide; Bromoacetyl bromide	598-21-0	C₂H₂Br₂O	详情	详情
(V)	35195	N-[bis(2-methylphenyl)methyl]-2-bromoacetamide		C₁₇H₁₈BrNO	详情	详情

Extended Information