2-(2,6-dimethylphenyl)-5-nitro-1H-isoindole-1,3(2H)-dione -Drug Synthesis Database

【结构式】

【分子编号】34935

【品名】2-(2,6-dimethylphenyl)-5-nitro-1H-isoindole-1,3(2H)-dione

【CA登记号】

【分子式】C₁₆H₁₂N₂O₄

【分子量】296.28236

【元素组成】C 64.86% H 4.08% N 9.45% O 21.6%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Phthalimide (III) was prepared by condensation of 4-nitrophthalic anhydride (I) with 2,6-dimethylaniline (II) in refluxing AcOH. Reduction of the nitro group of (II) by transfer hydrogenation using cyclohexene and Pd/C provided the title aminophthalimide.

参考文献中间体

合成目标

【1】 Vamecq, J.; Lambert, D.; Poupaert, J.H.; Masereel, B.; Stables, J.P.; Anticonvulsant activity and interactions with neuronal voltage-dependent sodium channel of analogues of ameltolide. J Med Chem 1998, 41, 18, 3307.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	31028	5-nitro-2-benzofuran-1,3-dione	5466-84-2	C₈H₃NO₅	详情	详情
(II)	17527	2,6-Xylidine; 2,6-Dimethylaniline; 2,6-Dimethylphenylamine	87-62-7	C₈H₁₁N	详情	详情
(III)	34935	2-(2,6-dimethylphenyl)-5-nitro-1H-isoindole-1,3(2H)-dione		C₁₆H₁₂N₂O₄	详情	详情

Extended Information