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【结 构 式】 
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【分子编号】34774 【品名】(2S)-2-[tert-butyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-(4-hydroxyphenyl)propionic acid 【CA登记号】 |
【 分 子 式 】C28H29NO5 【 分 子 量 】459.542 【元素组成】C 73.18% H 6.36% N 3.05% O 17.41% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVIII)Further coupling and deprotection cycles with N(epsilon)-Boc-lysine (I), and O-tert-butyl-tyrosine (XVIII), yielded the peptide resins (XVII) and (XIX), respectively. Then, acetylation of the free amino group of peptide resin (XIX) with Ac2O, and final deprotection and cleavage from the resin by means of moist trifluoroacetic acid, phenol and triisopropylsilane furnished the title peptide amide.
| 【1】 Aldrich, J.V.; Murray, T.F.; Wan, Q.; A novel acetylated analogue of dynorphin A-(1-11) amide as a kappa-opioid receptor antagonist. J Med Chem 1999, 42, 16, 3011. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 23540 | Phenol | 108-95-2 | C6H6O | 详情 | 详情 | |
| (I) | 18854 | (2S)-6-[(tert-butoxycarbonyl)amino]-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]hexanoic acid | C26H32N2O6 | 详情 | 详情 | |
| (XVI) | 34772 | C114H166N22O24S3 | 详情 | 详情 | ||
| (XVII) | 34773 | C125H186N24O27S3 | 详情 | 详情 | ||
| (XVIII) | 34774 | (2S)-2-[tert-butyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-(4-hydroxyphenyl)propionic acid | C28H29NO5 | 详情 | 详情 | |
| (XIX) | 34775 | C138H203N25O29S3 | 详情 | 详情 |
Extended Information