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【结 构 式】

【分子编号】34757

【品名】[(4S,6S)-4-isopropenyl-7-oxabicyclo[4.1.0]hept-1-yl]methanol

【CA登记号】

【 分 子 式 】C10H16O2

【 分 子 量 】168.23584

【元素组成】C 71.39% H 9.59% O 19.02%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

Sharpless asymmetric epoxidation of (S)-(-)-perillyl alcohol (I) using tert-butyl hydroperoxide and diethyl L-tartrate produced epoxide (II), which was reduced to diol (III) by means of LiAlH4 in cold THF. Treatment of (III) with 2,2-dimethoxypropane (IV) and p-toluenesulfonic acid then furnished the title isopropylidene ketal.

1 Ryder, H.; Skoumas, V.; Watson, M.; Moore, M.; Coombes, R.C.; Ashworth, P.A.; Donaldson, M.J.; XR 3054, structurally related to limonene, is a novel inhibitor of farnesyl protein transferase. Eur J Cancer 1999, 35, 6, 1014.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 34756 [(4S)-4-isopropenyl-1-cyclohexen-1-yl]methanol 536-59-4 C10H16O 详情 详情
(II) 34757 [(4S,6S)-4-isopropenyl-7-oxabicyclo[4.1.0]hept-1-yl]methanol C10H16O2 详情 详情
(III) 34758 1-(hydroxymethyl)-4-isopropenylcyclohexanol C10H18O2 详情 详情
(IV) 10722 1-Methoxy-1-methylethyl methyl ether; 2,2-Dimethoxypropane 77-76-9 C5H12O2 详情 详情
Extended Information