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【结 构 式】

【分子编号】34749

【品名】1-(2,6-dimethylphenoxy)-N-methyl-2-propanamine; N-[2-(2,6-dimethylphenoxy)-1-methylethyl]-N-methylamine

【CA登记号】

【 分 子 式 】C12H19NO

【 分 子 量 】193.289

【元素组成】C 74.57% H 9.91% N 7.25% O 8.28%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

Amine (I) was alkylated with 4-nitrophenethyl bromide (II) in refluxing isopropanol to yield the tertiary amine (III). Hydrogenation of the nitro group of (III) employing Pd/C afforded aniline (IV). Subsequent condensation of (IV) with methanesulfonyl chloride in the presence of Et3N produced the corresponding sulfonamide. The title compound was finally isolated as the hydrochloride salt.

1 Berzsenyi, P.; Druga, A.; Pátfalusi, M.; Varga, I.; Rettegi, T.; Barlocco, D.; Moravcsik, I.; Mátyus, P.; Papp, G.; Varró, A.; Cignarella, G.; Simay, A. (Albert Szent-Györgyi Medical University ; Gyogyszerkutato Intezet Kft.); Novel antiarrhythmic cpds.. WO 9929655 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
13467 Methanesulfonyl chloride;Mesyl chloride;Methylsulfonyl chloride;Methanesulfonic acid chloride;Methanesulfonyl chloride;Methanesulphonyl chloride 124-63-0 CH3ClO2S 详情 详情
(I) 34749 1-(2,6-dimethylphenoxy)-N-methyl-2-propanamine; N-[2-(2,6-dimethylphenoxy)-1-methylethyl]-N-methylamine C12H19NO 详情 详情
(II) 19191 1-(2-bromoethyl)-4-nitrobenzene 5339-26-4 C8H8BrNO2 详情 详情
(III) 34750 1-(2,6-dimethylphenoxy)-N-methyl-N-(4-nitrophenethyl)-2-propanamine; N-[2-(2,6-dimethylphenoxy)-1-methylethyl]-N-methyl-N-(4-nitrophenethyl)amine C20H26N2O3 详情 详情
(IV) 34751 N-(4-aminophenethyl)-N-[2-(2,6-dimethylphenoxy)-1-methylethyl]-N-methylamine; 4-[2-[[2-(2,6-dimethylphenoxy)-1-methylethyl](methyl)amino]ethyl]aniline C20H28N2O 详情 详情
Extended Information