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【结 构 式】 
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【分子编号】34676 【品名】N-[(E)-amino[(2-methoxyethyl)amino]methylidene]thiourea 【CA登记号】 |
【 分 子 式 】C5H12N4OS 【 分 子 量 】176.24264 【元素组成】C 34.08% H 6.86% N 31.79% O 9.08% S 18.19% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XV)An alternative procedure consisted in the bromination of acetophenone (V), followed by formation of the target thiazole by condensation of the resulting bromoacetophenone (VII) with [(2-methoxyethylamino)(amino)methylene]thiourea (XV).
| 【1】 Katsura, Y.; Tomishi, T.; Inoue, Y.; Takasugi, H. (Fujisawa Pharmaceutical Co., Ltd.); Guanidino thiazoles and their use as H2-receptor antagonist. EP 0545376; JP 1994321921; US 5532258 . |
| 【2】 Inoue, Y.; Morinaga, C.; Ishikawa, H.; Takasugi, H.; Tomishi, T.; Matsumoto, Y.; Katsura, Y.; Sakane, K.; Anti-Helicobacter pylori agents.4. 2-(Substituted guanidino)-4-phenylthiazoles and some structurally rigid derivatives. J Med Chem 2000, 43, 17, 3315. |
Extended Information