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【结 构 式】 
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【分子编号】34504 【品名】 【CA登记号】 |
【 分 子 式 】C47H67N11O8 【 分 子 量 】914.11832 【元素组成】C 61.76% H 7.39% N 16.85% O 14% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIII)The resin (X) was coupled with N-Boc-L-phenylalanine (XI) affording resin (XII). The acetylation of the free amino group, side-chain deprotection and cleavage from the resin (XII) employing liquid HF and p-cresol yielded the linear dipeptide (XIII). This was finally cyclized with benzotriazol-1-yloxytris (dimethylamino)phosphonium hexafluorophosphate (BOP) to produce the title cyclic peptide.
| 【1】 Wong, A.K.; Finch, A.M.; Pierens, G.K.; Craik, D.J.; Taylor, S.M.; Fairlie, D.P.; Small molecular probes for G-protein-coupled C5a receptors: Conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a. J Med Chem 1998, 41, 18, 3417. |
| 【2】 Wong, A.K.; Fairlie, D.P.; Finch, A.M.; Wadi, S.K.; Craik, D.J.; Taylor, S.M.; Paczkowski, N.J.; Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a. J Med Chem 1999, 42, 11, 1965. |
| 【3】 Fairlie, D.; Wong, A.; Finch, A.M.; Taylor, S.M. (University of Queensland); Cyclic agonists and antagonists of C5a receptors and G protein-coupled receptors. EP 1017713; WO 9900406 . |
Extended Information