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【结 构 式】 
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【分子编号】34362 【品名】4-ethyl-1,3-dihydro-2H-imidazol-2-one 【CA登记号】 |
【 分 子 式 】C5H8N2O 【 分 子 量 】112.1314 【元素组成】C 53.56% H 7.19% N 24.98% O 14.27% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The acid chloride (II) of isonicotinic acid is prepared by reaction of oxalyl chloride (A) with the potassium salt of isonicotinic acid (I). The acylation of 1,3-dihydro-4-ethyl-2H-imidazol-2-one (III) with acid chloride (II) under Friedel-Crafts' conditions gives 1,3-dihydro-4-isonicotinoyl-5-ethyl-2H-imidazol-2-one.
| 【1】 Dage, R.C.; Schnettler, R.A.; Palopoli, F.P.; 4-Aroyl-1,3-dihydro-2H-imidazol-2-ones, a new class of cardiotonic agents. Effect of 4-Pyridoyl substituents and related compounds. 186th ACS Natl Meet (Aug. 28 - Sept. 2, Washington, D.C.) 1983, Abst MEDI-84. |
| 【2】 Schnettler, R.A.; Dage, R.C.; Grisar, J.M.; Palopoli, F.P.; 4-Pyridylimidazolones and method of use. EP 0059948; ES 8305352; ES 8402827; GB 2096600; US 4405628 . |
| 【3】 Mannhold, R.; Piroximone. Drugs Fut 1984, 9, 12, 905. |
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