4-ethyl-1,3-dihydro-2H-imidazol-2-one -Drug Synthesis Database

【结构式】

【分子编号】34362

【品名】4-ethyl-1,3-dihydro-2H-imidazol-2-one

【CA登记号】

【分子式】C₅H₈N₂O

【分子量】112.1314

【元素组成】C 53.56% H 7.19% N 24.98% O 14.27%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The acid chloride (II) of isonicotinic acid is prepared by reaction of oxalyl chloride (A) with the potassium salt of isonicotinic acid (I). The acylation of 1,3-dihydro-4-ethyl-2H-imidazol-2-one (III) with acid chloride (II) under Friedel-Crafts' conditions gives 1,3-dihydro-4-isonicotinoyl-5-ethyl-2H-imidazol-2-one.

参考文献中间体

合成目标

【1】 Dage, R.C.; Schnettler, R.A.; Palopoli, F.P.; 4-Aroyl-1,3-dihydro-2H-imidazol-2-ones, a new class of cardiotonic agents. Effect of 4-Pyridoyl substituents and related compounds. 186th ACS Natl Meet (Aug. 28 - Sept. 2, Washington, D.C.) 1983, Abst MEDI-84.
【2】 Schnettler, R.A.; Dage, R.C.; Grisar, J.M.; Palopoli, F.P.; 4-Pyridylimidazolones and method of use. EP 0059948; ES 8305352; ES 8402827; GB 2096600; US 4405628 .
【3】 Mannhold, R.; Piroximone. Drugs Fut 1984, 9, 12, 905.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	29841	Oxalyl chloride; 2-Chloro-2-oxoacetyl chloride	79-37-8	C₂Cl₂O₂	详情	详情
(I)	34361	potassium isonicotinate		C₆H₄KNO₂	详情	详情
(II)	27850	isonicotinoyl chloride	39178-35-3	C₆H₄ClNO	详情	详情
(III)	34362	4-ethyl-1,3-dihydro-2H-imidazol-2-one		C₅H₈N₂O	详情	详情

Extended Information